Reply To: Using Omega 3’s and other COX 2 Inhibitors in our fertility patients

[Amy Galvan]

I would be concerned that upping the dose of fish oil (or other COX-2 inhibitors) would be a problem if the patient is trying to get pregnant because implantation, deciduation of the uterus, placenta development, and new microcirculation development require inflammatory cytokines that a COX-2 would shut down. Any time tissue is broken down and converted requires inflammatory signalling, as described in the research articles.

I am going back to Leah Hechtman’s lecture when she said Vitamin D needs to be 80 ng/mL. Vitamin D regulates cytokine signaling, rather than inhibits COX signaling.