Great list, Dr White! Here is another idea to ponder. . .

It is my understanding that phytoestrogens (particularly soy and flaxseed) can be used to DOWNregulate estrogen receptors, because they sit on the ER and stimulate it to a lesser degree than say estradiol (E2), in effect blocking E2 stimulation in a woman with true (not relative) estrogen dominance. By the same token of stimulating ERs, phytoestrogens can have the opposite effect to UPregulate estrogen in perimenopausal and postmenopausal women (women who produce much less E2), because these phytoestrogens have a minimal but additive effect on ER activity.

Does anyone have a comment on that?